STC2 and brain ischemia: These include DLGAP4, which encodes a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells and that plays a vital role in synaptic scaling by regulating the turnover rate of ionotropic and metabotropic glutamate receptors (95); STC2, which shows a neuroprotective effect during cerebral ischemia (96); and TEAD4, which belongs to a family of proteins known to regulate cortical development (97).