AKT1 and neoplasm: This modulation may be caused by a burdock active ingredient that has numerous pharmacological properties and has been shown to have anti-tumor, neuroprotective, antiviral, anti-inflammatory, anti-oxidant, and endoplasmic reticulum (ER) stress regulating actions through regulating NFkB, PI3K/AKT, and Stat pathways [[61], [62], [63]].