EDN1 and endothelial dysfunction: In endothelial dysfunction, various studies have demonstrated the role of ET-1 gene in augmenting ROS and increased production of O2- in human arteries and animal vessels (Elmarakby et al., 2005; Loomis et al., 2005; Böhm et al., 2007; Cerrato et al., 2012; Sánchez et al., 2014).