Accumulated epidemiological, clinical, and basic research evidence indicates that inflammatory markers and the hormonal pathway (e.g., interleukin-6, C-reactive protein, myokine, and serum testosterone) are involved in the association between sarcopenia and cognitive impairment (Shi et al., 2015; Scott et al., 2017; Sharma et al., 2021; Seo et al., 2022). The gene discussed is CRP; the disease is Cognitive impairment.