Stratified analyses by dyslipidemia showed that THSD1 rs3803264 AG/GG carriers had a significantly decreased risk of HS in the non-dyslipidemia group and normal lipid groups of TC, TG, HDL-C, and LDL-C [Adjusted ORs (95%CIs): 0.579 (0.422–0.793), 0.664 (0.522–0.843), 0.772 (0.614–0.970), 0.739 (0.591–0.925), and 0.721 (0.586–0.888), respectively]. The gene discussed is THSD1; the disease is metabolic syndrome.