The PITX3gene-associated diseases are cataract 11 (CATARACT 11, MULTIPLE TYPES; CTRCT11; OMIM: 610623; AD, AR) and anterior segment hypoplasia type 1 (ANTERIOR SEGMENT DYSGENESIS 1; ASGD1; OMIM: 107250; AD), which are consistent with the phenotypes of posterior polar cataract, corneal opacity, anterior segment hypoplasia, and other phenotypes in this family. This evidence concerns the gene AR and Alzheimer disease.