The mutations in genes that are critical to the development and maintenance of the lens structure (such as lensin, connexin, and aquaporin) are usually associated with isolated congenital cataracts, and the transcription factors PAX6, FOXE3, EYA1, MAF, and PITX3 have also been reported in congenital cataracts with ASDM [4]. Here, FOXE3 is linked to early-onset non-syndromic cataract.