Interestingly, paired recordings from neighboring pyramidal neurons and targeted optogenetic stimulation of PV interneurons revealed a selective deficit in the fidelity of action potential propagation and synaptic transmission, suggesting that a major contributor of NaV1.1 loss of conductance to the pathophysiology of DS could relate to its role at the nodes of Ranvier (Figure 1) (48). Here, SCN1A is linked to Dravet syndrome.