In addition, Miao et al. demonstrated that PAMK can reduce liver injury by reducing oxidative stress-related insulin resistance or by directly changing the expression of genes involved in liver lipid metabolism, such as catalase (CAT), heme oxygenase 1 (HO-1), glutathione peroxidase (GSH-Px), and NQO1 (39). Here, HMOX1 is linked to Insulin resistance.