Hypoalphalipoproteinemia includes the following diseases: Tangier disease, Apolipoprotein A-I (APOA1) deficiency, and Lecithin cholesterol acyltransferase (LCAT) deficiency (including Familial LCAT deficiency (FLD) and Fish eye disease (FED)) (Hegele 2020 review). This evidence concerns the gene APOA1 and Tangier disease.