We took advantage of the finding that PD-L1 correlates with signatures of metabolic activity and angiogenesis at a single-cell scale (Figure 4) when designing our biophysics-based PD-L1 expression probability maps, as follows: Within our biophysical simulations, we identified a signature of metabolic activity related to in vivo glucose use by the tumor that directly influences tumor growth behavior. The gene discussed is CD274; the disease is neoplasm.