A role for WASp in the control of RICD and autoimmunity was observed in lymphocytes from WASp KO mice (22) but not by us in human lymphocytes silenced for WASp; this discrepancy is putatively due to the experimental systems used (total genetic ablation in murine lymphocytes vs silencing in humans PBLs). The gene discussed is WAS; the disease is Autoimmunity.