CD274 and intrahepatic cholangiocarcinoma: Multivariate analysis showed that PD-L1 could act as an independent predictor for OS (HR, 1.48; 95% CI, 1.14-1.91; P = 0.003) and RFS (HR, 1.74; 95% CI, 1.22-2.47; P = 0.002), and PD1 acted as an independent predictor for OS (HR, 1.66; 95% CI, 1.15-2.38; P = 0.006).<h4>Conclusion</h4>This meta-analysis demonstrated that high PD-L1/PD1 expression is associated with poor survival in ICC.