Through the study of sigmoid colon from patients with Hirschsprung’s disease in 2008, it was found that the nubmer of ICCs expressing c-kit decreased significantly, while the number of ICCs expressing CD34 did not decrease, so it was pointed out that the specific downregulation of c-kit in ICCs may be a cause of sigmoid megacolon (87). Here, KIT is linked to Hirschsprung disease.