CHRNA7 and intestinal obstruction: In a model of postoperative intestinal obstruction in mice and humans (characterized by a surgically induced inflammatory response in intestinal myenteric macrophages and impaired intestinal motility), vagal stimulation or pharmacological action on cholinergic enteric neurons prevented myenteric macrophage activation and reduced postoperative intestinal obstruction in a α7 nicotinic receptor (α7nAChR) dependent manner (14).