NLRP6 and infection: It has been found that wild-type mice infected with an attenuated Salmonella typhimurium (spiB) can clear the infection within 7-10 days, but the result of infection is long-term (up to 4 months) impairment of gastrointestinal motility and reduction of intestinal neurons in a NLRP6/Caspase11-dependent manner.