TNF and COVID-19: Although the study has relevant information for a better understanding of how genetic variations in immune response components may be associated with the severity of COVID-19, it has some limitations, mainly related to the lack of evaluation of other polymorphisms in the MBL2 gene and the expression of immune components that induce the production of TNF-α and IL-6 cytokines such as TLR-3 and TLR-7.