The MMRGs had few single nucleotide polymorphisms (SNPs) in patients in the TCGA-LAML cohorts, only three genes (SUCLA2, SURF1, and POLG) with somatic mutations among 31 MMRGs in three AML patiens (Figure 2A, Figure S2A), mainly missense mutation. The gene discussed is POLG; the disease is acute myeloid leukemia.