The ROC curves showed that expression levels of COX10 (AUC = 0.650, Figure S4C), NDUFA1 (AUC = 0.673, Figure S4H), and TIMM8A (AUC = 0.630, Figure S4R) had lower accuracy in distinguishing two AML subtypes, while the expression levels of BCS1L (Figure S4B), DGUOK (Figure S4D), ECHS1 (Figure S4E), ETHE1 (Figure S4F), MPV17 (Figure S4G), NDUFA13 (Figure S4I), NDUFS2 (Figure S4J), NDUFS7 (Figure S4K), NDUFV1 (Figure S4L), POLG (Figure S4M), SDHA (Figure S4N), SUCLG1 (Figure S4O), SURF1 (Figure S4P), and TACO1 (Figure S4Q) could accurately distinguish the two AML subtypes (Figures S4B–R). Here, ECHS1 is linked to acute myeloid leukemia.