The mutation profile of the 31 MMRGs in AML samples was analyzed to evaluate the mutation characteristic of the 31 MMRGs (BCS1L, COX10, COX15, DGUOK, ECHS1, ETHE1, FBXL4, LIAS, MPV17, NDUFA1, NDUFA13, NDUFAF5, NDUFS1, NDUFS2, NDUFS4, NDUFS7, NDUFV1, NFU1, POLG, POLG2, SDHA, SDHD, SLC25A4, SUCLA2, SUCLG1, SURF1, TACO1, TIMM8A, TMEM70, TRIT1, TTC19). The gene discussed is COX15; the disease is acute myeloid leukemia.