Several authors examined European and Asian populations using genome-wide association studies (GWAS) of genes and discovered significant differences in some genes between healthy people and rheumatoid arthritis patients, especially ZKSCAN4, ABCF1, BTN3A3, BRD2, FLOT1, HLA-DMA, HLA-G, HLA-F, HSP90AB1, IER3, and TUBB (71). This evidence concerns the gene IER3 and rheumatoid arthritis.