A search of the GEO database revealed that RNF170 protein expression was significantly increased in human monocytes after infection with human immunodeficiency virus (HIV) (61), and when the body’s fibroblasts underwent an immune response to cytomegalovirus infection, the expression level of RNF170 protein in fibroblasts showed a trend of first increasing and then decreasing (62), and in general, RNF170 is extremely important in natural immunity. Here, RNF170 is linked to infection.