IL6 and neoplasm: Through the release of signaling molecules including transforming growth factor beta (TGF-),macrophage colony-stimulating factor (M-CSF), vascular endothelial growth factor (VEGF),inflammatory cytokines or chemokines (IL-10, IL-6, and CXCL-8) (78–80), and extracellular vesicles (EV) with immunosuppressive qualities (81), they are involved in the beginning and advancement of the tumor.