MiR-21-5p and miR-200a derived from small extracellular vesicles (sEVs) synergistically induced M2-like TAM polarization through the PTEN/AKT and SCOS1/STAT1 pathways leading to decreased CD8+ T cell activity, and thus contributed to immune escape and CRC tumor growth (98). The gene discussed is AKT1; the disease is colorectal carcinoma.