Similar to miR-934, the miR-25-3p, miR-130b-3p and miR-425-5p, derived from exosomes of CRC cells and upregulated by CXCL12/CXCR4 axis activation, also regulated the M2 polarization of macrophages through the PTEN/PI3K/Akt signaling pathway, and the serum levels of these miRNAs correlated with the progression and metastasis of CRLM (97). Here, AKT1 is linked to colorectal carcinoma.