MAPK1 and Hepatic fibrosis: Overexpression of miR-130a-3p by the lentivirus vector (LV-miR-130a-3p) could alleviate liver granulomatous inflammation and liver fibrosis; moreover, LV-miR-130a-3p promoted the polarization of macrophages towards the restorative Ly6Clo phenotype, inhibited the activation and proliferation of HSCs and also induced the apoptosis of HSCs by inhibiting MAPK1 expression (49).