used a mouse model of CCl4-induced liver fibrosis to demonstrate that the expression of exosomal miR-500 was upregulated in LPS-induced macrophages, and exosomal miR-500 overexpression could promote the proliferation and activation of HSCs and accelerate liver fibrosis by inhibiting mitochondrial fusion protein 2 (MFN2) (111). This evidence concerns the gene MFN2 and Hepatic fibrosis.