MiR-1246 has been detected to be highly expressed in the serum exosomes of colon cancer patients (100); miR-1246-enriched exosomes from TP53 mutant (mutp53) colon cancer cells could trigger the reprogramming of neighboring macrophages to a tumor-supporting and anti-inflammatory state, which was associated with poor survival in colon cancer patients (101). This evidence concerns the gene TP53 and colonic neoplasm.