In a mouse model of sepsis-related acute lung injury, exosomal miR-30d-5p of TNF-α-stimulated neutrophils promoted M1 macrophage polarization and induced macrophage pyroptosis through activating NF-κB signaling by targeting the suppressor of cytokine signaling (SOCS-1) and SIRT1 both in vivo and in vitro (58). The gene discussed is SIRT1; the disease is Sepsis.