TNF and brain injury: The exosomal miR-30d-5p of TNF-α-stimulated neutrophils promoted M1 macrophage polarization in a mouse model of sepsis-related acute lung injury (58), whereas miR-30d-5p-enriched exosome from the adipose-derived stem cell suppressed M1 microglial polarization in acute ischemic stroke-induced brain injury (59).