ACSL4 and cancer: Xanthohumol (2) is a principal prenylated chalcone isolated from hops with its anti-inflammatory, anti-oxidative, and cancer-preventive properties (Zhou et al., 2021; Neumann et al., 2022; Vicente de Andrade Silva et al., 2023).2 protect cardiomyocytes against Fe-SP- and RSL3-induced ferroptosis by decreasing the production of lipid peroxidation and ROS, chelating iron, increasing the Nrf2 and GPX4 protein, while decreasing the mRNA levels of Ptgs2 and Acsl4, and the protein levels of ACSL4 (Lin et al., 2022).