18, a natural polyphenol phytochemical derived from turmeric with antioxidant, anti-inflammatory, and anticancer properties, activates Nrf2/HO-1 signaling to relieve diabetic cardiomyopathy injury (Ren et al., 2020; Wu et al., 2020; Wei et al., 2021; Wu S. et al., 2022).18 alleviates DCM through inhibiting ferroptosis by activating Nrf2, leading to upregulating GPX4, highlighting a potentially new therapeutic route for investigation for the treatment DCM(Wei J. et al., 2022). Here, GPX4 is linked to familial dilated cardiomyopathy.