In a variety of human tumors, family with sequence similarity 83 member A was initially identified by bioinformatics methods as a potential tumor-specific gene with overexpression, including in bladder, lung, testicular, breast cancers, etc. Chen et al. found that in pancreatic cancer FAM83A shows significant overexpression, which promotes CSC-like features by activating Wnt/β-catenin and TGF-β pathways. Here, TGFB1 is linked to familial pancreatic carcinoma.