The formula as followed: RiskScore = + 0.134*ANLN-0.086*SCAMP5+0.048*FAM83A-0.111*ATP2A3+0.322*CEP55 + 0.11*GJB4+0.1*COL17A1 Single-cell division TISCH2 (http://tisch.comp-genomics.org/home/) analyzed the expression distribution of seven genes in multiple single-cell data of pancreatic cancer, and the results showed that the expression of COL17A1 and FAM83A genes in malignant cells was significantly higher than that in other cell types (Supplementary Figure S3). This evidence concerns the gene GJB4 and familial pancreatic carcinoma.