SNAI2 plays a crucial role in regulating T-cell lineages (Pioli et al., 2016) and cancer cell stemness (Chen et al., 2021; Peng et al., 2022), as well as modulating lapatinib resistance in HER2-positive breast cancer (Hamalian et al., 2021) and enhancing 5-fluorouracil sensitivity in colorectal cancer (Findlay et al., 2014). Here, SNAI2 is linked to colorectal cancer.