In another study (Adaikkan et al., 2019), the same group investigated the P301S tauopathy model and another model called CK-p25, which are known to exhibit neurodegeneration (synaptic and neuronal loss) and cognitive deficit at an early age due to tau hyperphosphorylation and formation of neurofibrillary tangles. The gene discussed is MAPT; the disease is tauopathy.