The three plastin isoforms expressed in mammals include I-plastin, with tissue restriction to the intestine and kidney; T-plastin, with a broad tissue distribution; and LPL, expressed normally in hematopoietic cells but may also be ectopically expressed in cancer cells of several origins, including breast, prostate, and colon cancer (Delanote et al., 2005; Samstag and Klemke, 2007; Morley, 2012). Here, LPL is linked to cancer.