We labelled the siRNA transfected MDA and MDA-BrM cells with CTG and performed a HUVEC adhesion assay; for both MDA and MDA-BrM, reduced cell surface expression of CD146 was associated with significantly increased adhesion to HUVEC monolayers at certain time points in the assay (p < 0.05–p < 0.0001; Figure 3C) revealing that CD146 expression inhibits breast cancer-EC adhesion. The gene discussed is MCAM; the disease is breast cancer.