Furthermore, others have reported that CD146 plays a positive role in breast cancer cell migration, albeit using the parental MDA-MB-231 cell line (or other breast cancer cell lines) and not the brain metastatic variant of MDA-MB-231 (Zabouo et al., 2009; Imbert et al., 2012; Zeng et al., 2012). The gene discussed is MCAM; the disease is breast cancer.