According to Mathiyalagan and colleagues, silencing miR-126-3p in CD34+-EVs derived from G-CSF mobilized PB-MNCs eliminated their angiogenic behavior and other constructive activities in vitro as well as in vivo. In addition, infusion of CD34+-EVs improved miR-126-3p levels in mouse ischemic limbs while having no impact on endogenous miR-126-3p synthesis, implying a horizontal transfer of efficient miR-126-3p to the ischemia site (Mathiyalagan et al., 2017). This evidence concerns the gene CD34 and ischemia.