Most importantly, the study of SMCR8 knockout mice has revealed that they develop autoimmunity similarly to C9ORF72 deficient animals (Zhang et al., 2018; Liang et al., 2019), but they also display mild motor phenotypes (Zhang et al., 2018) resembling those observed in C9ORF72 knockout mice (Atanasio et al., 2016; Jiang et al., 2016) and in our model. The gene discussed is SMCR8; the disease is Autoimmunity.