On the other hand, knockout mice have been produced unraveling some of the functions of the C9ORF72 protein without extensively investigating behavioral characteristics of these mice, particularly in relation to FTD (Atanasio et al., 2016; Burberry et al., 2016; O’Rourke et al., 2016; Sudria-Lopez et al., 2016). The gene discussed is C9orf72; the disease is frontotemporal dementia.