The impact of joint IMIDs on the incidence of anxiety was more prominent in male patients (p-interaction = 0.0001), those who were current smokers (p-interaction = 0.0142) and heavy alcohol drinkers (p-interaction = 0.0011), those without hypertension (p-interaction < 0.0001), stroke (p-interaction = 0.0002), ischemic heart disease (p-interaction = 0.0265) and COPD (p-interaction < 0.0001), patients not using insulin (p-interaction < 0.0001), and those who had a disease duration of T2DM of <5 years (p-interaction = 0.0004; Figure 4E). The gene discussed is INS; the disease is Stroke.