ACOX1 and X-linked adrenoleukodystrophy: The autophagy induction observed mainly in the Abcd1−/−Abcd2−/− genotype seems to be in contradiction with the impaired autophagic flux observed in X-ALD fibroblasts and presented as a neuroprotective mechanism (Launay et al., 2015) but fits with the increased autophagy observed in case of Acox1 defect (He et al., 2020).