Some of these results (induction of Smpd1, Cerk, Sphk1, and repression of Acer2, Cers3, Cers4) are in agreement with the transcriptomic data obtained from patient fibroblasts with cerebral or adrenomyeloneuropathy forms of X-ALD showing that the anabolic pathway toward sphingolipids and glycosphingolipids is downregulated (Lee et al., 2019). Here, CERS4 is linked to X-linked adrenoleukodystrophy.