In the hippocampus, Grin2a plays a crucial role in synaptogenesis and synaptic plasticity (Marwick et al., 2015), Tenm3 may orchestrate the assembly of topographic circuit assembly in the hippocampus (Berns et al., 2018), Shisa6 is a plausible candidate gene for Alzheimer’s disease and is associated with post-synaptic transmission (Ramos et al., 2022), and up-regulated Map1b may promote axon growth (Wang et al., 2022). Here, TENM3 is linked to early-onset autosomal dominant Alzheimer disease.