CFL1 and leukemia: Previous studies show that activation of cofilin has a key role in mediating secretion in different tissues (Mizuno, 2013), including insulin secretion (Jayaram and Kowluru, 2012), parotoid exocrine secretion (Takuma et al., 1996), platelet degranulation (Pandey et al., 2009) and histamine release from basophilic leukemia cells (Sakuma et al., 2012).