It is likely, judging by the roles of cofilin in cellular functions of other cells with other stimuli (Ohashi, 2015; Xu et al., 2021) that cofilin also plays additional roles in both other physiological (development, etc.)and pathophysiological effects in pancreatic acini (pancreatitis, pancreatic cancer growth and pathogenesis). Here, CFL1 is linked to pancreatitis.