In regard to pancreatic function, cofilin has been shown to be important in the regulation of insulin secretin by pancreatic islets (Jayaram and Kowluru, 2012), to be important in pancreatic tumor growth and metastatic behavior, similar to its role in other cancers (Xu et al., 2021), and in pancreatic acinar depolymerization/reorganization (Xu et al., 2021), which is important in the pathogenesis of pancreatitis (Yang et al., 2022). This evidence concerns the gene CFL1 and pancreatitis.