An amelioration was also observed in mice following the administration of the rGDF11 protein in a rheumatoid arthritis model, alleviating the arthritis phenotype that could be associated with the inhibition of the NF-κB pathway and downregulation of pro-inflammatory cytokines Tnf, Il1b, and Il6 expression (Li et al., 2019). This evidence concerns the gene NFKB1 and arthritic joint disease.