Regarding IBDs, GDF11 was able to ameliorate UC in a mice model through inhibition of NLRP3 inflammasome complex, the main responsible for the maturation of pro-inflammatory cytokine IL-1β and markedly present in mucositis induced by 5-FU (Soares et al., 2013; Wang et al., 2018). The gene discussed is NLRP3; the disease is mucositis.