IL10 and colitis: Cytokine IL-10 has a significant effect on the TGI since knockout of Il10 or its receptor leads to colitis predisposition in experimental models as well as reduction of circulating levels of IL-10 were found in mice with mucositis, and increased levels were crucial in attenuating mucositis in mice treated with Lactobacillus acidophilus (Justino et al., 2015; Jain et al., 2017).