TNF and arthritic joint disease: Moreover, in the search for new therapeutical molecules, the potential anti-inflammatory role of GDF11 has only recently begun to be elucidated on different experimental models such as arthritis (Li et al., 2019), psoriasis (Wang et al., 2019), and UC (Wang et al., 2018) in mice, where it has demonstrated a suppression role in the pro-inflammatory NF-κB pathway and lowered expression levels of pro-inflammatory cytokines TNF, IL-1β, and IL-6 (Wang et al., 2018, 2019; Li et al., 2019).