To corroborate the role of FOXO3 in cardiomyocyte apoptosis and autophagy involved in DCM progression, transgenic mice with inducible cardiac‐specific knockout of the FOXO3 gene (Myh6‐CreERT2, FOXO3 flox+/+) were engineered before Dox administration (Figure S6A). This evidence concerns the gene FOXO3 and familial dilated cardiomyopathy.