FOXO3 and familial dilated cardiomyopathy: Data from an echocardiographic evaluation suggested that the absence of cardiac FOXO3 significantly ameliorated the aberrant motion of the left ventricular wall (Figure 7E), improved cardiac function (Figure 7F,G), reduced the enlargement of the ventricle (Figure 6H) and delayed ventricular wall thinning in DCM progression (Figure 7I,J).