Delivery of a combination of miR‐30c‐5p, miR‐126‐5p and miR‐126‐3p into the murine myocardium via AAV9 carrying an expression cassette driven by cTnT promoter, or cardiac‐specific knockout of FOXO3 (Myh6‐CreERT2, FOXO3 flox+/+) dramatically attenuated cardiac apoptosis and autophagy involved in DCM progression. This evidence concerns the gene TNNT2 and familial dilated cardiomyopathy.