FOXO3 and familial dilated cardiomyopathy: Similarly, cardiac inactivation of FOXO3 by p844, 45 or silencing of FOXO3 via gene knockout (Figure 7A,B) evidently diminished DCM myocardium autophagy and improved cardiac function, corroborating the seditious status of FOXO3 in regulating muscular autophagy and atrophy.