To elaborate on the role of DACMs‐FOXO3 regulatory axis in DCM pathogenesis, a construct expressing RNA transcript bearing a wild‐type 3′ untranslated region (3′UTR) of FOXO3 gene (wild‐type, FOX3‐3′UTR‐WT) was generated to competitively disrupt the interaction between DACMs and the 3′UTR of endogenous FOXO3 mRNA. Here, RBFOX3 is linked to familial dilated cardiomyopathy.