In CRC cells, miR‐21 was proven to directly target the core MMR proteins (hMSH2 and hMSH6),46 while miR‐155 over‐expression also significantly down‐regulated the core MMR proteins (hMLH1, hMSH2 and hMSH6) inducing a mutator phenotype (MSI).47 This evidence concerns the gene MSH6 and colorectal carcinoma.