Down‐regulation of miR‐149‐3p subsequently promoted PHD‐finger domain protein 5A (PHF5A)‐mediated RNA alternative splicing of lysine acetyltransferase 2A (KAT2A) and transactivated superoxide dismutase‐2 (SOD2) in CRC cells, which finally led to the occurrence of CAC69 (Figure 4). Here, KAT2A is linked to colorectal carcinoma.