P21 can promote cell cycle arrest in the G1 phase [59]; Pten can inhibit prostate tumor cell proliferation by inhibition of PI3K/Akt pathway [60–62]; Ki67 is central to the cell cycle; and high phosphorylation of Ki67 usually occurs in mitosis cells, all of which indicated that there is an enhanced proliferation of hybrid cells. The gene discussed is AKT1; the disease is prostate neoplasm.