IFNB1 and neoplasm: GO enrichment of up-regulated genes or up-regulated proteins in hybrid tumor cells revealed that a number of immune regulation pathways were significantly enriched, including response to interferon-beta, negative regulation of the immune system process, positive regulation of response to an external stimulus, cytokine-mediated signaling pathway, and antigen processing and presentation (Fig. 2i, j), which were similar to the results of myeloid-like disseminated tumor cells found in humans (Fig. 1f).