MAPT and Alzheimer disease: Nevertheless, the inclusion of prodromal AD patients with a higher risk of rapid clinical progression characterized by an higher initial temporoparietal tau load and younger age will require great caution in interpreting the evolution of the SUVr values, which could be biased by a paradoxical decrease in some regions (potentially explained by a decrease of the tissue’s ability to retain pathologic aggregates over time or by a rapid transition to ghost tangles, for which the affinity of the tracer is lower).