MAPT and Mental deterioration: In contrast, we found a strong association between the progression of regional cortical atrophy and cognitive decline, depending on the cognitive component considered and congruent in anatomical-functional terms (memory and temporal lobes, instrumental functions and parietal cortex, and executive functions and fronto-parietal cortex), which is similar to what has been recently reported in the study of the predictive value of the baseline tau-PET [7].