More importantly, we found that in the HRisk group, the expression of immune checkpoints (SIRPA, LILRB1, SIGLEC10) of tumor associated macrophages involved in tumor antigen recognition disorders increased significantly, and the increased binding of CD47-SIRPA [41] and MHCI/ LILRB1 [42] would lead to tyrosine phosphorylation on immune receptor tyrosine—based on inhibitory motifs (ITIMs), release the "don't eat me" signal, So as to inhibit macrophage mediated phagocytosis and protect normal cells from damage of immune system. The gene discussed is CD47; the disease is neoplasm.