In order to verify the stability of the results of the above correlation analysis in different populations and exclude the effect of potential reverse causality on the results, based on Model III, we further considered the possible effect of liver enzyme-related parameters (ALT, AST, and GGT) on the risk of diabetes in Sensitivity-1, and excluded subjects with a follow-up period of less than 2 years, fatty liver diagnosed at baseline, and overweight/obesity in Sensitivity 2–4, respectively. The gene discussed is GPT; the disease is obesity due to melanocortin 4 receptor deficiency.