Up-regulated NUF2 in ccRCC patients was significantly correlated with gender, pathological stage, tumor grade, and lymph node metastasis, especially in men, patients with high tumor stage and grade, and multiple lymph node metastases, suggesting that high expression of NUF2 may be an adverse prognostic factor in RCC patients (Fig. 2). The gene discussed is NUF2; the disease is nonpapillary renal cell carcinoma.