OVOL2 and colonic neoplasm: The promoter CGI of OVOL2 was hypermethylated in colon cancer cells HCT116 compared with normal colon tissue (Fig. 5B), and the level of H3K4me1/3 at promoter CGIs of OVOL2 was significantly increased in LSD1 KO cells, the DNA methylation level at promoter CGI of OVOL2 was comparable between control and LSD1 KO or LSD1 OE cells (Fig. 5B).