PITX2 and Juvenile glaucoma: They found that MYOC (myocilin), FOXC1 (forkhead box C1), PITX2 (paired like homeodomain 2), and CYP1B1 (cytochrome P450 family 1 subfamily B) are both strongly implicated in juvenile glaucoma and ocular hypertension and highly expressed in TM and ciliary muscle cell types.