Utilizing Everolimus, the APCMin/+ mouse model crossed with EIF4E S209A knockin and BID knockout strains, and normal human colonic epithelial cells, we demonstrated that mTOR inhibition selectively induces ER stress and apoptosis in Myc-high cells caused by APC loss, which promotes a cell-death-dependent local immune response and tumor control. This evidence concerns the gene APC and neoplasm.