Engineering of DNAJB1-PRKACAfus in human hepatocytes induced only some typical features also noted in FLC, such as a certain degree of hepatocyte dedifferentiation and a Wnt signature, but their cellular and molecular phenotypes were in general much milder with fewer cancer stemness features than what was observed in the BAP1KO;PRKAR2AKO organoids. Here, DNAJB1 is linked to cancer.