Single nucleotide polymorphisms (SNPs) at the RNF186 locus (p.R179X) have been directly linked to elevated serum creatinine levels and chronic kidney disease in a genome-wide association study conducted on Icelandic individuals [49], and RNF186 R179X has been characterized as a loss-of-function mutation [50]. The gene discussed is RNF186; the disease is chronic kidney disease.