GPR17 downregulation promotes the development of mature oligodendrocytes from myelin-producing oligodendrocyte precursors.469 GPR17 is involved in reconstructing and repairing demyelinating plaques formed by ongoing inflammatory processes.470 In a mouse model of multiple sclerosis, targeting GPR17 can delay the onset of autoimmune encephalomyelitis.471. This evidence concerns the gene GPR17 and multiple sclerosis.