ADGRB3 and bipolar disorder: Adhesion G protein-coupled receptor B3 (ADGRB3) is enriched in post-synaptic density and cerebellar Purkinje cells.563,567,568 ADGRB3 modulates synaptic connection in the cerebellum.568 SNPs and gene amplification in ADGRB3 are associated with familial schizophrenia.569 Other psychiatric conditions, such as bipolar disorder, are suggested to be linked with ADGRB3.570