HTR1A and Timothy syndrome: TS is commonly coupled with obsessive-compulsive disorder (OCD) and ADHD.442 The underlying mechanism of TS remains poorly clarified.443–445 Abnormalities in synaptic neurotransmission involved in the cortico-striatal-thalamocortical circuitry are implicated in TS pathogenesis.446,447 Dopaminergic signaling in cortico-striatal-thalamocortical pathways might be associated with TS progression.444,448,449 α-adrenergic agonists are the first choice in TS treatment.450 Examples include Clonidine and Guanfacine.438,451 Aripiprazole is a partial agonist of dopamine D2 and 5-HT1A receptors.