HSPG2 and psychiatric disorder: Calcium signaling is essential for the release of neurotransmitters.37,38 For instance, dysregulation of the dopamine D1 receptor-mediated PLC/IP3/Ca2+ pathway in the anterior cortex of the brain is associated with mental illness in rats.39,40 PLC/IP3/Ca2+ pathway regulates the electrical response of the neuron.41 Impaired Ca2+ homeostasis by Aβ exposure is one of the underlying causes of amyloid toxicity in Alzheimer’s disease.42 In psychiatric disorders, Ca2+ signaling regulates neuronal connectivity, synaptic plasticity, and glial functions.43