It is a post-synaptic dopamine D2 receptor antagonist, a presynaptic dopamine D2 receptor partial agonist, and a 5-HT2A receptor antagonist.392 Lumateperone can be used for positive & negative symptoms and cognitive dysfunction in schizophrenia.393 It can also be used in bipolar disorder treatment.393. Here, DRD2 is linked to schizophrenia.