To the best of our knowledge, this is the first study to assess the diagnostic accuracy of different clinical diagnostic criteria (SB, DLCC, and FAMCAT) in identifying FH in the Malaysian primary care setting, with molecular diagnosis targeting the 4 FHCGs (LDLR, APOB-100, PCSK9, and LDLRAP1) as the gold standard. The gene discussed is APOB; the disease is familial hyperaldosteronism.