After adjusting for confounding variables, the best interactive model for carotid atherosclerosis (increased CCA‐IMT, vulnerable plaque) was the interaction among TNFSF4 rs1234313, IL1A rs1609682, TLR4 rs1927911, ITGA2 rs1991013, NOS2A rs2297518, IL6R rs4845625, ITGA2 rs4865756, HABP2 rs7923349, NOS2A rs8081248, HABP2 rs932650. This evidence concerns the gene IL6R and carotid atherosclerosis.