The oncogenic role of high mobility group A (HMGA) proteins stems from chromatin‐mediated activation of cancer‐driving genes such as E2F transcription factor 1 (E2F1), Activator protein‐1 (AP1), and Cyclin A1 (CCNA1), as well as the repression of tumor suppressive genes such as TP53.31 The gene discussed is E2F1; the disease is cancer.