Logistic regression analysis indicated that serum potassium (OR 0.311, 95% CI 0.103‐0.935), serum sodium levels (OR 0.991, 95% CI 0.983‐1.000), CRH levels (OR 0.964, 95% CI 0.936‐0.994), and blood glucose (OR 1.654, 95% CI 1.137‐2.406) in the perioperative period were independent risk factors for delirium. This evidence concerns the gene CRH and delirium.