FURIN and cystic fibrosis: While nonselective inhibitors of furin such as decanoyl-RVKR-CMK and QUB-TL1 demonstrated a reduction in PE-induced cytotoxicity in CF AECs [29], similar studies using a highly selective furin inhibitor, BOS-318, have confirmed the role of furin in the PE intoxication process and adds further weight to the therapeutic potential of furin inhibition in the airways [54].