Moreover, NVB impaired the growthof FANCF-deficient TOV21G cancer cells (human ovarian cancer withreduced HR capacity) in a mouse xenograft study without affectingFANCF-complemented cells (TOV21G with FANCF cDNA).Results obtained in vivo were further confirmed by in vitro CSA, which showed that NVB significantlyreduced the survival of BRCA1–/– and BRCA2–/– (TP53–/–) RPE1 cells, compared to isogenic WT cells. The gene discussed is FANCF; the disease is ovarian cancer.