BRCA1 and cancer: Compoundsshowed IC50 values comparable to those of the analoguespreviously mentioned, ranging from 0.32 to 5.56 μM in BRCA1–/– RPE1cells and from 0.59 to 7.95 μM BRCA1wt in cells, the highest selectivity ratio being 2.8.Additionally, the antiproliferative activity of the 14 small moleculeswas evaluated in a panel of 11 cancer cell lines, but results weredisclosed only for 10 compounds in the MCF7 and SKBR3 cell lines,with IC50s ranging from 0.4 to 5.1 μM and from 0.24to 5.2 μM, respectively (as example, activity of compound 26 was reported in Figure 11c).